![]() ![]() The ability to control systemic metabolism with respect to nutrient content is due to so-called nutrient sensing pathways. The funders did not play any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Īnimal physiology is constantly readjusted in changing nutrient landscape. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The RNAseq data is available in GEO, with the accession number GSE166681.įunding: Funding was provided by: Academy of Finland (MetaStem Center of Excellence funding 312439) to VH, Sigrid Juselius Foundation to VH, Novo Nordisk Foundation (NNF18OC0034406 and NNF19OC0057478) to VH, Jane and Aatos Erkko Foundation to VH, and Integrative Life Science Doctoral Program to NL. Received: FebruAccepted: OctoPublished: October 11, 2021Ĭopyright: © 2021 Kokki et al. Barsh, HudsonAlpha Institute for Biotechnology, UNITED STATES (2021) Metabolic gene regulation by Drosophila GATA transcription factor Grain. Collectively, our study provides evidence for the role of a metazoan GATA transcription factor in nutrient-responsive metabolic gene regulation in vivo.Ĭitation: Kokki K, Lamichane N, Nieminen AI, Ruhanen H, Morikka J, Robciuc M, et al. Consistently with these differential tissue-specific roles, Grain deficient larvae display delayed development on high sugar diet, while showing deregulated central carbon and lipid metabolism primarily on low sugar diet. On the other hand, grain displays strong constitutive expression in the anterior midgut, where it drives lipogenic gene expression also under low sugar conditions. grain expression is activated by sugar in Mondo-Mlx-dependent manner and it contributes to sugar-responsive gene expression in the fat body. De novo motif prediction uncovered a significant over-representation of GATA-like motifs on the promoters of sugar-activated genes in Drosophila larvae, which are regulated by Grain, the fly ortholog of GATA1/2/3 subfamily. ![]() Here we identify a role for Drosophila GATA TF Grain in metabolic gene regulation under both low and high sugar conditions. TFs that correspondingly control sugar responsive metabolic genes under conditions of low dietary sugar remain, however, poorly understood. In Drosophila, dietary sugars activate transcription factors (TFs), such as Mondo-Mlx, Sugarbabe and Cabut, which control metabolic gene expression to mediate physiological adaptation to high sugar diet. One alternative is Garmin.Nutrient-dependent gene regulation critically contributes to homeostatic control of animal physiology in changing nutrient landscape. There’s plenty of competition in this market, but TomTom is the easiest, and most efficient, option. #Tomtom home 2.7.6 macTomTom is available for most mobile devices and can be updated with, or without, Windows and Mac computers. This makes it easy to find the quickest route to your destination. Use this application and get live traffic reports. You can track fuel prices for every gas station while on your journey. There is a category called 'other features' and here you can store your favorite music, photos, and HTML documents on your device. TomTom has some very interesting features. TomTom lets you purchase, or update, the maps for wherever you are headed. ![]() #Tomtom home 2.7.6 softwareThe main software interface shows all the available content, sorted into categories, so you can operate the device in a personalized way. Through this process, you’ll manage your maps and other navigation needs very easily. Getting into it, once the software has been downloaded, connect your device to your computer and TomTom Home will automatically recognize it. If you’re looking for a great way to quickly find your destination, there are a variety of devices and software dedicated to helping you out. Getting from point A to point B can be as simple as following your avatar on a screen. ![]()
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